All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.
Things begin to unravel when one of the survivors goes rogue and takes matters into their own hands — risking the lives of everyone on the island (source: ABCmedianet).
Bree considers selling her business to save her marriage. Lynette is threatened by her new boss, and boundaries are crossed for Gabrielle and Carlos. Meanwhile, Katherine is caught in the most unexpected of circumstances and Edie’s worst fears come true.
When Chelsea gets sick, Charlie takes care of her—but he also tries to resist the urge to flee.
Charlie declares his love to Chelsea (Jennifer Taylor), but he isn’t prepared for the response he receives.
With Chelsea soon to arrive, Charlie must find a way to get a half-naked date out of his bedroom.
Jesse’s mission takes a turn for the worst, which results in unexpected consequences for Sarah, John, and Derek. Meanwhile, Sarah deals with Cameron and John makes a very important decision.