Part one of a two-hour season finale. Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark is ready to take his relationship with Lexie to the next level. A patient makes Owen reassess his place at Seattle Grace and Izzie’s surgery to remove the brain tumor has dire consequences. This is the second hour of a 2-hour season premiere. A two episode entries have been created. The 10pm EST marker will mark to beginning of the second episode.
In the first part of the two hour season finale, Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark is ready to take his relationship with Lexie to the next level and a patient makes Owen reassess his place at Seattle Grace. This is the first hour of a 2-hour season premiere. A two episode entries have been created. The 10pm EST marker will mark to beginning of the second episode.
It’s Meredith and Derek’s wedding day, but as the day progresses could another couple end up getting married instead? Izzie is confronted with cancer once again when she meets another cancer patient. (portrayed by Liza Weil) Derek gives Meredith a wedding gift (her first solo surgery).
As preparations continue for Meredith and Derek’s wedding, several residents must face the arrival of their parents at the hospital: Izzie’s mother Robbie causes a stir when she pays a surprise visit, and Thatcher returns to make amends with Meredith and Lexie. The Chief clashes with Meredith over a controversial medical case.
Amidst a series of intense treatments, Izzie throws herself into Derek and Meredith’s wedding plans, but the stress of her illness takes its toll on Alex - who freezes during surgery just as George begins to excel. Meanwhile: Callie’s father arrives at Seattle Grace, but is less than pleased to meet his daughter’s girlfriend; Owen seeks help to quell his PTSD outburtsts.
All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.
After his fellow surgeons try and fail to bring Derek back to work, Meredith must summon the strength to convince him. Meanwhile the hospital is abuzz as Mark attempts a rare face transplant surgery. Cristina, at last awarded her first solo surgery, is more focused on the needs of her friends, and Izzie does her best to keep her medical condition a secret.
